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Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human Ace2 Receptor

2020-07-29

Abstract excerpt

The current COVID-19 pandemic is caused by the SARS-CoV-2 betacoronavirus, which utilizes its highly glycosylated trimeric Spike protein to bind to the cell surface receptor ACE2 glycoprotein and facilitate host cell entry.  We utilized glycomics-informed glycoproteomics to characterize site-specific microheterogeneity of glycosylation for a recombinant trimer Spike mimetic immunogen and for a soluble version of h...

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Literature Corpus work
08bcf70b-525f-5b8c-9ffd-cd828b7dc8d5
DOI
10.2139/ssrn.3641894
Open publication

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Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human Ace2 ReceptorDOI 10.2139/ssrn.3641894
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