Article

Structural Genetics of circulating variants affecting the SARS-CoV-2 Spike / human ACE2 complex

2020-09-09

Abstract excerpt

SARS-CoV-2 entry in human cells is mediated by the interaction between the viral Spike protein and the human ACE2 receptor. This mechanism evolved from the ancestor bat coronavirus and is currently one of the main targets for antiviral strategies. However, there currently exist several Spike protein variants in the SARS-CoV-2 population as the result of mutations, and it is unclear if these variants may exert a sp...

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Literature Corpus work: 294cb6b9-c3c2-5f1c-ad49-9411bd5c3865
DOI: 10.1101/2020.09.09.289074

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