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Article

Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein.

Journal of medical virology - 1 Sept 2020

Hussain Mushtaq, Jabeen Nusrat, Raza Fozia, Shabbir Sanya, Baig Ayesha A, Amanullah Anusha, Aziz Basma

Abstract excerpt

The recent pandemic of COVID-19, caused by SARS-CoV-2, is unarguably the most fearsome compared with the earlier outbreaks caused by other coronaviruses, SARS-CoV and MERS-CoV. Human ACE2 is now established as a receptor for the SARS-CoV-2 spike protein. Where variations in the viral spike protein, in turn, lead to the cross-species transmission of the virus, genetic variations in the host receptor ACE2 may also...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 32249956
DOI: 10.1002/jmv.25832
PMCID: PMC7228372

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