Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural genetics of circulating variants affecting the SARS-CoV-2 spike/human ACE2 complex.

Journal of biomolecular structure & dynamics - 1 Sept 2022

Ortuso Francesco, Mercatelli Daniele, Guzzi Pietro Hiram, Giorgi Federico Manuel

Abstract excerpt

SARS-CoV-2 entry in human cells is mediated by the interaction between the viral Spike protein and the human ACE2 receptor. This mechanism evolved from the ancestor bat coronavirus and is currently one of the main targets for antiviral strategies. However, there currently exist several Spike protein variants in the SARS-CoV-2 population as the result of mutations, and it is unclear if these variants may exert a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme 2
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Peptidyl-Dipeptidase A

Share to Protein Binding

Share to SARS-CoV-2

Share to SARS-CoV-2 and COVID-19 Research

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 33583326
DOI: 10.1080/07391102.2021.1886175
PMCID: PMC7885719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural genetics of circulating variants affecting the SARS-CoV-2 spike/human ACE2 complex.PMID 33583326Read ↗

Structural Genetics of circulating variants affecting the SARS-CoV-2 Spike / human ACE2 complexSemantic proximity Read ↗

Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein.Semantic proximity Read ↗

Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity.Semantic proximity Read ↗

Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity.Semantic proximity Read ↗

Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased Transmissibility.Semantic proximity Read ↗

Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spikeSemantic proximity Read ↗

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein.Semantic proximity Read ↗

Structural modeling of the SARS-CoV-2 Spike/human ACE2 complex interface can identify high-affinity variants associated with increased transmissibilitySemantic proximity Read ↗

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike proteinSemantic proximity Read ↗

Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein.Semantic proximity Read ↗

SARS-CoV-2 Spike receptor-binding domain with a G485R mutation in complex with human ACE2Semantic proximity Read ↗

A modular molecular framework for quickly estimating the binding affinity of the spike protein of SARS-CoV-2 variants for ACE2, in presence of mutations at the spike receptor binding domainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.