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Article

Significance of targeting DNMT3A mutations in AML.

Annals of hematology - 1 Mar 2025

Huang Guiqin, Cai Xiaoya, Li Dengju

Abstract excerpt

Acute myeloid leukemia (AML) is the most prevalent form of leukemia among adults, characterized by aggressive behavior and significant genetic diversity. Despite decades of reliance on conventional chemotherapy as the mainstay treatment, patients often struggle with achieving remission, experience rapid relapses, and have limited survival prospects. While intensified induction chemotherapy and allogeneic stem...

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Topics

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methylation
Share to DNA Methyltransferase 3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Molecular Targeted Therapy

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 39078434
DOI: 10.1007/s00277-024-05885-8
PMCID: PMC12031811

Genes

DNMT3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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