Article

DNMT3A Mutations in Acute Myeloid Leukemia

2011-11-18

Abstract excerpt

Abstract Abstract SCI-31 DNMT3A is one of the two human de novo methyltransferases; both are essential for methylating specific cytosine residues, a process that is critical for regulating gene expression during early development. In 2010, recurring mutations in DNMT3A were discovered in patients with AML (1, 2); mutations were not found in the other de novo methyltransferase (DNMT3B) or in the binding partner for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f937bd93-f27d-574c-ae15-6ccd91b396c5
DOI: 10.1182/blood.v118.21.sci-31.sci-31

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNMT3A Mutations in Acute Myeloid LeukemiaDOI 10.1182/blood.v118.21.sci-31.sci-31Read

DNMT3A mutations in acute myeloid leukemia.Semantic proximity Read

Acute myeloid leukemia with DNMT3A mutations.Semantic proximity Read

Characteristics of DNMT3A mutations in acute myeloid leukemiaSemantic proximity Read

DNMT3A mutations in acute myeloid leukemiaSemantic proximity Read

[DNMT3A gene mutations in acute myeloid leukemia].Semantic proximity Read

DNMT3A in Leukemia.Semantic proximity Read

Significance of targeting DNMT3A mutations in AML.Semantic proximity Read

AML-Associated Mutations in DNA Methyltransferase DNMT3A.Semantic proximity Read

DNMT3A in haematological malignancies.Semantic proximity Read

DNMT3A mutations are rare in childhood acute myeloid leukemia.Semantic proximity Read

DNMT3A mutations in Chinese childhood acute myeloid leukemia.Semantic proximity Read

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.Semantic proximity Read