Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypomethylation coordinates antagonistically with hypermethylation in cancer development: a case study of leukemia

1 Jul 2016

Abstract excerpt

BACKGROUND: Methylation changes are frequent in cancers, but understanding how hyper- and hypomethylated region changes coordinate, associate with genomic features, and affect gene expression is needed to better understand their biological significance. The functional significance of hypermethylation is well studied, but that of hypomethylation remains limited. Here, with paired expression and methylation samples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27461342
DOI: 10.1186/s40246-016-0071-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypomethylation coordinates antagonistically with hypermethylation in cancer development: a case study of leukemiaPMID 27461342Read ↗

Aberrant DNA methylation is co-regulated across the genome in leukemia and other types of cancerSemantic proximity Read ↗

Uncovering the DNA methylome in chronic lymphocytic leukemiaSemantic proximity Read ↗

Deconvolution of cancer methylation patterns determines that altered methylation in cancer is dominated by a non-disease associated proliferation signalSemantic proximity Read ↗

Epigenetic and genetic alterations and their influence on gene regulation in chronic lymphocytic leukemia.Semantic proximity Read ↗

Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemiaSemantic proximity Read ↗

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networksSemantic proximity Read ↗

Epigenetic deregulation in chronic lymphocytic leukemia: Clinical and biological impactSemantic proximity Read ↗

Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemiaSemantic proximity Read ↗

The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemiaSemantic proximity Read ↗

New insights on the role of DNA methylation from a global view.Semantic proximity Read ↗

Genomic and Epigenomic Alterations in Chronic Lymphocytic Leukemia.Semantic proximity Read ↗

Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.