Article

Aberrant DNA methylation is co-regulated across the genome in leukemia and other types of cancer

2026-06-09

Abstract excerpt

Epigenetic dysregulation is a defining feature of cancer, but it remains poorly understood how this is coordinated across the genome. In this study we focusd on DNA methylation (DNAm) in acute myeloid leukemia (AML). Despite highly heterogeneous and largely patient-specific patterns, we identified co-regulated clusters of CpGs that could be assembled into reproducible epigenetic networks. Multilinear regression mo...

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Literature Corpus work: f34f5a16-569f-5abf-994e-8ad3c529c9f5
DOI: 10.64898/2026.06.05.729844

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