Article

Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML

2023-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation of poorly differentiated myeloid cells, with a heterogenous mutational landscape. Mutations in IDH1 and IDH2 are found in 20% of the AML cases. Although much effort has been made to identify genes associated with leukemogenesis, the regulatory mechanism of AML state transition is still not fully understood. To alleviate...

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Literature Corpus work: 04f32cd9-7d8a-548d-a569-f9c595f3404a
DOI: 10.1101/2023.07.29.551111

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