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Article

Polygenic risk scores: how much do they add?

Current opinion in lipidology - 1 Jun 2021

Christoffersen Mette, Tybjærg-Hansen Anne

Abstract excerpt

PURPOSE OF REVIEW: Current methods to assess genetic risk of familial hypercholesterolemia and coronary artery disease (CAD) focus on testing monogenic mutations in well known genes. Here we review recent developments in polygenic risk scores (PRSs) for LDL cholesterol and for CAD, and how they may add to current risk prediction algorithms. RECENT FINDINGS: PRSs can identify 10-20 times as many individuals at...

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Identifiers

PMID: 33900274
DOI: 10.1097/MOL.0000000000000759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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