A mechanistic framework for cardiometabolic and coronary artery diseases.

doi:10.1038/s44161-021-00009-1

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Article

A mechanistic framework for cardiometabolic and coronary artery diseases.

Nature cardiovascular research - 1 Jan 2022

Koplev Simon, Seldin Marcus, Sukhavasi Katyayani, Ermel Raili, Pang Shichao, Zeng Lingyao, Bankier Sean, Di Narzo Antonio, Cheng Haoxiang, Meda Vamsidhar, Ma Angela, Talukdar Husain, Cohain Ariella, Amadori Letizia, Argmann Carmen, Houten Sander M, Franzén Oscar, Mocci Giuseppe, Meelu Omar A, Ishikawa Kiyotake, Whatling Carl, Jain Anamika, Jain Rajeev Kumar, Gan Li-Ming, Giannarelli Chiara, Roussos Panos, Hao Ke, Schunkert Heribert, Michoel Tom, Ruusalepp Arno, Schadt Eric E, Kovacic Jason C, Lusis Aldon J, Björkegren Johan L M

Abstract excerpt

Coronary atherosclerosis results from the delicate interplay of genetic and exogenous risk factors, principally taking place in metabolic organs and the arterial wall. Here we show that 224 gene-regulatory coexpression networks (GRNs) identified by integrating genetic and clinical data from patients with (n = 600) and without (n = 250) coronary artery disease (CAD) with RNA-seq data from seven disease-relevant...

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PMID: 36276926
DOI: 10.1038/s44161-021-00009-1
PMCID: PMC9583458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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