Article
Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States.
PLoS genetics - 1 Sept 2017
Shu Le, Chan Kei Hang K, Zhang Guanglin, Huan Tianxiao, Kurt Zeyneb, Zhao Yuqi, Codoni Veronica, Trégouët David-Alexandre, Yang Jun, Wilson James G, Luo Xi, Levy Daniel, Lusis Aldons J, Liu Simin, Yang Xia
Abstract excerpt
Cardiovascular diseases (CVD) and type 2 diabetes (T2D) are closely interrelated complex diseases likely sharing overlapping pathogenesis driven by aberrant activities in gene networks. However, the molecular circuitries underlying the pathogenic commonalities remain poorly understood. We sought to identify the shared gene networks and their key intervening drivers for both CVD and T2D by conducting a...
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