Article
Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse.
eLife - 7 Dec 2023
Kurt Zeyneb, Cheng Jenny, Barrere-Cain Rio, McQuillen Caden N, Saleem Zara, Hsu Neil, Jiang Nuoya, Pan Calvin, Franzén Oscar, Koplev Simon, Wang Susanna, Björkegren Johan, Lusis Aldons J, Blencowe Montgomery, Yang Xia
Abstract excerpt
Mouse models have been used extensively to study human coronary artery disease (CAD) or atherosclerosis and to test therapeutic targets. However, whether mouse and human share similar genetic factors and pathogenic mechanisms of atherosclerosis has not been thoroughly investigated in a data-driven manner. We conducted a cross-species comparison study to better understand atherosclerosis pathogenesis between...
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