Article

Genetic Insight into the Paradoxical Relationship among Diabetes, Coronary Artery Disease, and Abdominal Aortic Aneurysm

2024-12-26

Abstract excerpt

Type 2 diabetes (T2D) increases the risk of coronary artery disease (CAD) but decreases that for abdominal aortic aneurysm (AAA), forming an intriguing diabetes-atherosclerosis paradox. We investigate its genetic basis employing techniques such as genetic correlation, colocalization, gene annotation, functional enrichment, and pathway pairing on GWAS datasets. We discover a strong and positive correlation between...

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Literature Corpus work: 1f01f476-b4d1-517f-8098-93628cfaef78
DOI: 10.1101/2024.12.24.24319595

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