Article
Multiple independent mechanisms link gene polymorphisms in the region of ZEB2 with risk of coronary artery disease.
Atherosclerosis - 1 Oct 2020
Ma Lijiang, Chandel Nirupama, Ermel Raili, Sukhavasi Katyayani, Hao Ke, Ruusalepp Arno, Björkegren Johan L M, Kovacic Jason C
Abstract excerpt
BACKGROUND AND AIMS: Coronary artery disease (CAD) arises from the interaction of genetic and environmental factors. Although genome-wide association studies (GWAS) have identified multiple risk loci and single nucleotide polymorphisms (SNPs) associated with risk of CAD, they are predominantly located in non-coding or intergenic regions and their mechanisms of effect are largely unknown. Accordingly, our...
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