Article
5' Rapid amplification of cDNA ends (5'RACE): A simpler method to analyze immunoglobulin genes and discover the value of the light chain in chronic lymphocytic leukemia.
Leukemia research - 1 Dec 2022
Lan Xuan, Ruminy Philippe, Bohers Elodie, Rainville Vinciane, Viennot Mathieu, Viailly Pierre-Julien, Etancelin Pascaline, Tilly Hervé, Mihailescu Sorina, Bouclet Florian, Leprêtre Stéphane, Jardin Fabrice
Abstract excerpt
The mutational status of the variable region of the immunoglobulin heavy chain gene (IGHV) is a very important biomarker for chronic lymphocytic leukemia (CLL) patients. However, the routine detection of IGHV mutational status is time-consuming and costly. Therefore, we performed 5' Rapid amplification of cDNA ends (5' RACE) in 81 CLL patients who previously underwent detection using Biomed-2. The agreement rate...
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