RNA sequencing detects more challenging cases of somatic hypermutation in the IgHV gene in patients with chronic lymphocytic leukemia.

doi:10.55730/1300-0144.6357

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Article

RNA sequencing detects more challenging cases of somatic hypermutation in the IgHV gene in patients with chronic lymphocytic leukemia.

Turkish journal of medical sciences - 1 Jan 2026

Arikan Fatma, Ata Pınar, Demir Şenol, Uluköylü Mengüç Meral, Özkalemkaş Fahir, Orhan Bedrettin, Mehtap Özgür, Bayar Arda, Yilmaz Asu Fergün, Tuğlular Ayşe Tülin, Atagündüz Işık, Toptaş Tayfur

Abstract excerpt

Background/aim: Chronic lymphocytic leukemia (CLL) exhibits marked biological heterogeneity, and immunoglobulin heavy chain variable (IgHV) mutation status remains a key prognostic biomarker. We evaluated patient IgHV status via RNA sequencing (RNA-seq) and examined real-life clinical outcomes in a retrospective CLL cohort. Materials and methods: Eighty-seven adults diagnosed with CLL between 2020 and 2022 at...

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Topics

Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Male
Somatic Hypermutation, Immunoglobulin
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Retrospective Studies

Middle Aged

Sequence Analysis, RNA

Immunoglobulin Heavy Chains

Aged

Mutation

Prognosis

Immunoglobulin Variable Region

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42677266
DOI: 10.55730/1300-0144.6357
PMCID: PMC13528727

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