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Article

Reading the B-cell receptor immunome in chronic lymphocytic leukemia: revelations and applications.

Experimental hematology - 1 Jan 2021

Hengeveld Paul J, Levin Mark-David, Kolijn P Martijn, Langerak Anton W

Abstract excerpt

B-Cell receptor (BCR) sequencing has been the force driving many recent advances in chronic lymphocytic leukemia (CLL) research. Here, we discuss the general principles, revelations, and applications of reading the BCR immunome in the context of CLL. First, IGHV mutational status, obtained by measuring the mutational imprint on the IGHV gene of the CLL clonotype, is the cornerstone of CLL risk stratification....

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Share to High-Throughput Nucleotide Sequencing
Share to Immunogenetic Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Receptors, Antigen, B-Cell

Share to V(D)J Recombination

Source

Identifiers

PMID: 32976948
DOI: 10.1016/j.exphem.2020.09.194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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