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Article

LC-FACSeq is a method for detecting rare clones in leukemia.

JCI insight - 18 Jun 2020

Hu Eileen Y, Blachly James S, Saygin Caner, Ozer Hatice G, Workman Stephanie E, Lozanski Arletta, Doong Tzyy-Jye, Chiang Chi-Ling, Bhat Seema, Rogers Kerry A, Woyach Jennifer A, Coombes Kevin R, Jones Daniel, Muthusamy Natarajan, Lozanski Gerard, Byrd John C

Abstract excerpt

Detecting, characterizing, and monitoring rare populations of cells can increase testing sensitivity, give insight into disease mechanism, and inform clinical decision making. One area that can benefit from increased resolution is management of cancers in clinical remission but with measurable residual disease (MRD) by multicolor FACS. Detecting and monitoring genomic clonal resistance to treatment in the setting...

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Identifiers

PMID: 32554930
DOI: 10.1172/jci.insight.134973
PMCID: PMC7406301

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