Next-CLL, a New Next-Generation Sequencing-Based Method for Assessment of IGHV Gene Mutational Status in Chronic Lymphoid Leukemia.

doi:10.1016/j.jmoldx.2023.01.009

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Article

Next-CLL, a New Next-Generation Sequencing-Based Method for Assessment of IGHV Gene Mutational Status in Chronic Lymphoid Leukemia.

The Journal of molecular diagnostics : JMD - 1 May 2023

Bourbon Estelle, Chabane Kaddour, Mosnier Isabelle, Bouvard Anne, Thonier Florian, Ferrant Emmanuelle, Michallet Anne-Sophie, Poulain Stéphanie, Hayette Sandrine, Sujobert Pierre, Huet Sarah

Abstract excerpt

Current guidelines for patients with chronic lymphocytic leukemia (CLL) recommend mutation status determination of the clonotypic IGHV gene before treatment initiation to guide the choice of first-line therapy. Currently, commercially available next-generation sequencing (NGS) solutions have technical constraints, as they necessitate at least a 2 × 300 bp sequencing, which restricts their use for routine...

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PMID: 36773701
DOI: 10.1016/j.jmoldx.2023.01.009

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