The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study.

doi:10.1158/1078-0432.CCR-18-0133

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Article

The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2018

Stamatopoulos Basile, Smith Thomas, Crompot Emerence, Pieters Karlien, Clifford Ruth, Mraz Marek, Robbe Pauline, Burns Adam, Timbs Adele, Bruce David, Hillmen Peter, Meuleman Nathalie, Mineur Philippe, Firescu Radu, Maerevoet Marie, De Wilde Virginie, Efira André, Philippé Jan, Verhasselt Bruno, Offner Fritz, Sims David, Heger Andreas, Dreau Hélène, Schuh Anna

Abstract excerpt

Purpose: Unmutated (UM) immunoglobulin heavy chain variable region (IgHV) status or IgHV3-21 gene usage is associated with poor prognosis in chronic lymphocytic leukemia (CLL) patients. Interestingly, IgHV3-21 is often co-expressed with light chain IgLV3-21, which is potentially able to trigger cell-autonomous BCR-mediated signaling. However, this light chain has never been characterized independently of the...

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PMID: 29945996
DOI: 10.1158/1078-0432.CCR-18-0133

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The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study.PMID 29945996Read ↗

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