Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics.

Blood - 27 May 2021

Nadeu Ferran, Royo Romina, Clot Guillem, Duran-Ferrer Martí, Navarro Alba, Martín Silvia, Lu Junyan, Zenz Thorsten, Baumann Tycho, Jares Pedro, Puente Xose S, Martín-Subero José I, Delgado Julio, Campo Elías

Abstract excerpt

B-cell receptor (BCR) signaling is crucial for chronic lymphocytic leukemia (CLL) biology. IGLV3-21-expressing B cells may acquire a single point mutation (R110) that triggers autonomous BCR signaling, conferring aggressive behavior. Epigenetic studies have defined 3 CLL subtypes based on methylation signatures reminiscent of naïve-like (n-CLL), intermediate (i-CLL), and memory-like (m-CLL) B cells with different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to B-Lymphocytes

Share to DNA Methylation

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Point Mutation

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 33211804
DOI: 10.1182/blood.2020008311
PMCID: PMC8191863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics.PMID 33211804Read ↗

IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling.Semantic proximity Read ↗

Genetics and epigenetics of CLL.Semantic proximity Read ↗

Molecular pathogenesis of chronic lymphocytic leukemia.Semantic proximity Read ↗

Molecular map of chronic lymphocytic leukemia and its impact on outcome.Semantic proximity Read ↗

Molecular pathogenesis of CLL and its evolution.Semantic proximity Read ↗

Identification of novel, clonally stable, somatic mutations targeting transcription factors PAX5 and NKX2-3, the epigenetic regulator LRIF1, and BRAF in a case of atypical B-cell chronic lymphocytic leukemia harboring a t(14;18)(q32;q21).Semantic proximity Read ↗

The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemiaSemantic proximity Read ↗

The mutational landscape of chronic lymphocytic leukemia and its impact on prognosis and treatmentSemantic proximity Read ↗

SnapShot: Chronic Lymphocytic Leukemia.Semantic proximity Read ↗

The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study.Semantic proximity Read ↗

Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia.Semantic proximity Read ↗

The spectrum of immunoglobulin heavy chain enhancer hijacking in chronic lymphocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.