Article
Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2015
Blachly James S, Ruppert Amy S, Zhao Weiqiang, Long Susan, Flynn Joseph, Flinn Ian, Jones Jeffrey, Maddocks Kami, Andritsos Leslie, Ghia Emanuela M, Rassenti Laura Z, Kipps Thomas J, de la Chapelle Albert, Byrd John C
Abstract excerpt
Immunoglobulins (Ig) are produced by B lymphocytes as secreted antibodies or as part of the B-cell receptor. There is tremendous diversity of potential Ig transcripts (>1 × 10(12)) as a result of hundreds of germ-line gene segments, random nucleotide incorporation during joining of gene segments into a complete transcript, and the process of somatic hypermutation at individual nucleotides. This recombination and...
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