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Immunoglobulin gene analysis in chronic lymphocytic leukemia in the era of next generation sequencing

19 Jun 2020

Abstract excerpt

Twenty years after landmark publications, there is a consensus that the somatic hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene is an important cornerstone for accurate risk stratification and therapeutic decision-making in patients with chronic lymphocytic leukemia (CLL). The IGHV SHM status has traditionally been determined by conventional Sanger sequencing. However, NGS...

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PMID: 32561841
DOI: 10.1038/s41375-020-0923-9

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