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Reliable one-step assessment of IGHV mutational status and gene mutations in Chronic Lymphocytic Leukemia by capture-based high throughput sequencing

2022-03-10

Abstract excerpt

Proper management of chronic lymphocytic leukemia (CLL) patients requiring therapy relies on two important prognostic and theranostic molecular features: respectively, the mutational status of tumoral cells immunoglobulin heavy chain variable domain ( IGHV) and the characteristics of TP53 . Both these (immuno)genetic analyses require multiple time-consuming amplification and sequencing techniques by Sanger or HT...

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Literature Corpus work
1b7b2c13-b864-549d-b7d0-4e7845e2dc01
DOI
10.1101/2022.03.09.483581
Open publication

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Reliable one-step assessment of IGHV mutational status and gene mutations in Chronic Lymphocytic Leukemia by capture-based high throughput sequencingDOI 10.1101/2022.03.09.483581
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