Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement.

doi:10.1038/s41375-024-02499-x

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Article

Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement.

Leukemia - 1 Mar 2025

Nabki Jana, Al Deeban Bashar, Sium Abel Mehari, Cosentino Chiara, Almasri Mohammad, Awikeh Bassel, Maher Nawar, Bellia Matteo, Dondolin Riccardo, Mouhssine Samir, Talotta Donatella, Secomandi Eleonora, Kogila Sreekar, Ghanej Joseph, Maiellaro Francesca, Cividini Luca, Rasi Silvia, Chiarenza Annalisa, Olivieri Jacopo, Gentile Massimo, Zaja Francesco, Del Principe Maria Ilaria, Laurenti Luca, Bomben Riccardo, Vit Filippo, Bittolo Tamara, Zucchetto Antonella, Gattei Valter, Gaidano Gianluca, Moia Riccardo

Abstract excerpt

The mutational status of immunoglobulin (IG) light chain genes in chronic lymphocytic leukemia (CLL) and its clinical impact have not been extensively studied. To assess their prognostic significance, the IG light chain gene repertoire in CLL patients has been evaluated using a training-validation approach. In the training cohort (N = 573 CLL), 92.5% showed productive IG light chain genes rearrangements, with...

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PMID: 39690182
DOI: 10.1038/s41375-024-02499-x
PMCID: PMC11879880

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