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Article

Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits.

Nature communications - 21 Oct 2022

Grotzinger Andrew D, de la Fuente Javier, Davies Gail, Nivard Michel G, Tucker-Drob Elliot M

Abstract excerpt

Functional genomic methods are needed that consider multiple genetically correlated traits. Here we develop and validate Transcriptome-wide Structural Equation Modeling (T-SEM), a multivariate method for studying the effects of tissue-specific gene expression across genetically overlapping traits. T-SEM allows for modeling effects on broad dimensions spanning constellations of traits, while safeguarding against...

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Identifiers

PMID: 36271044
DOI: 10.1038/s41467-022-33724-9
PMCID: PMC9586980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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