Article

The Genetic Architecture of Brain Structure and Function: A Data-Driven Interpretation Using genomICA

2025-04-09

Abstract excerpt

Understanding the genetic basis of individual differences in human brain structure and function remains a major challenge. Traditional genome-wide association studies (GWAS) have identified numerous genetic variants associated with brain phenotypes, but their interpretation is complicated by polygenicity and pleiotropy. To address this, we applied genomICA, a data-driven multivariate method, to GWAS summary statis...

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Literature Corpus work: bc3b4d4f-32af-595e-b84d-691c3ed06fa5
DOI: 10.1101/2025.04.07.25324950

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