Article
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis.
Nature genetics - 1 May 2022
Grotzinger Andrew D, Mallard Travis T, Akingbuwa Wonuola A, Ip Hill F, Adams Mark J, Lewis Cathryn M, McIntosh Andrew M, Grove Jakob, Dalsgaard Søren, Lesch Klaus-Peter, Strom Nora, Meier Sandra M, Mattheisen Manuel, Børglum Anders D, Mors Ole, Breen Gerome, Lee Phil H, Kendler Kenneth S, Smoller Jordan W, Tucker-Drob Elliot M, Nivard Michel G
Abstract excerpt
We interrogate the joint genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four broad factors (neurodevelopmental, compulsive, psychotic and internalizing) that underlie genetic correlations among the disorders and test whether these factors adequately explain their genetic correlations with biobehavioral traits. We...
Topics
- Genetic Predisposition to Disease
- Genome
- Genome-Wide Association Study
- Genomics
- Humans
- Mental Disorders
- Molecular Biology
- Polymorphism, Single Nucleotide