Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Genetic risk modeling approaches to resolve phenotypic and molecular heterogeneity in psychiatric disorders.

Current opinion in genetics & development - 1 Jun 2026

Kim Soo-Whee, Kim Yujin, Kim Il Bin, An Joon-Yong

Abstract excerpt

Psychiatric disorders are highly heterogeneous, with variable symptoms, illness course, and treatment response that complicate diagnosis and management. Genetic risk modeling approaches have increasingly been used to quantify individual differences in liability across and within diagnostic categories. Among these, polygenic risk scores have evolved from modest predictors of disease risk to tools for stratifying...

Topics

Humans
Mental Disorders
Genetic Predisposition to Disease
Phenotype
Genetic Risk Score
Models, Genetic
Genome-Wide Association Study
Multifactorial Inheritance
Genetic Heterogeneity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 41916154
DOI: 10.1016/j.gde.2026.102468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic risk modeling approaches to resolve phenotypic and molecular heterogeneity in psychiatric disorders.PMID 41916154Read ↗

Polygenic risk scores in psychiatry: Will they be useful for clinicians?Semantic proximity Read ↗

Shared genetic architecture across psychiatric disorders.Semantic proximity Read ↗

Ten challenges for clinical translation in psychiatric genetics.Semantic proximity Read ↗

Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis.Semantic proximity Read ↗

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders.Semantic proximity Read ↗

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disordersSemantic proximity Read ↗

Research review: Polygenic methods and their application to psychiatric traits.Semantic proximity Read ↗

Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record dataSemantic proximity Read ↗

Assessing the evidence for shared genetic risks across psychiatric disorders and traits.Semantic proximity Read ↗

Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?Semantic proximity Read ↗

Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores.Semantic proximity Read ↗

Polygenic risk scores in psychiatry - Large potential but still limited clinical utility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.