Article
Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas.
Molecular cell - 20 Oct 2022
Shi Zhumei, Ge Xin, Li Mengdie, Yin Jianxing, Wang Xiefeng, Zhang Junxia, Chen Dongyin, Li Xinjian, Wang Xiuxing, Ji Jing, You Yongping, Qian Xu
Abstract excerpt
Cancer-specific TERT promoter mutations have been linked to the reactivation of epigenetically silenced TERT gene by creating de novo binding motifs for E-Twenty-Six transcription factors, especially GABPA. How these mutations switch on TERT from epigenetically repressed states to expressed states have not been defined. Here, we revealed that EGFR activation induces ERK1/2-dependent phosphorylation of...
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