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Article

TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions.

Cancer discovery - 1 Nov 2016

Min Jaewon, Shay Jerry W

Abstract excerpt

Although single-nucleotide somatic mutations in the proximal promoter of the human telomerase reverse transcriptase (TERT) gene create novel consensus sequences for transcription factors that enhance TERT expression, the precise mechanism of how telomerase is reactivated in cancer cells remains poorly understood. In this issue, Akıncılar and colleagues identify a potential mechanism of TERT reactivation that is...

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Share to Cell Line, Tumor
Share to Chromatin
Share to Chromosomes, Human, Pair 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 27807101
DOI: 10.1158/2159-8290.CD-16-1050
PMCID: PMC5111399

Genes

TERT
GABPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions.PMID 27807101Read ↗

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Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new playersSemantic proximity Read ↗

Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with EpigeneticsSemantic proximity Read ↗

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