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Article

Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E.

Endocrinology and metabolism (Seoul, Korea) - 1 Sept 2020

Song Young Shin, Park Young Joo

Abstract excerpt

The telomerase reverse transcriptase (TERT) gene, which is repressed in most differentiated human cells, can be reactivated by somatic TERT alterations and epigenetic modulations. Moreover, the recruitment, accessibility, and binding of transcription factors also affect the regulation of TERT expression. Reactivated TERT contributes to the development and progression of cancer through telomere...

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Share to Cell Transformation, Neoplastic
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Share to Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 32981294
DOI: 10.3803/EnM.2020.304
PMCID: PMC7520576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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