Article
Genetic architecture underlying IgG-RF production is distinct from that of IgM-RF.
Rheumatology (Oxford, England) - 2 May 2023
Yaku Ai, Ishikawa Yuki, Iwasaki Takeshi, Hiwa Ryosuke, Matsuo Keitaro, Saji Hiroh, Yurugi Kimiko, Miura Yasuo, Furu Moritoshi, Ito Hiromu, Fujii Takao, Maekawa Taira, Hashimoto Motomu, Ohmura Koichiro, Mimori Tsuneyo, Terao Chikashi
Abstract excerpt
OBJECTIVE: HLA-DRB1 alleles, particularly the shared epitope (SE) alleles, are strongly associated with RA. Different genetic structures underlie the production of the various autoantibodies in RA. While extensive genetic analyses have been conducted to generate a detailed profile of ACPA, a representative autoantibody in RA, the genetic architecture underlying subfractions of RF other than IgM-RF, namely IgG-RF,...
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