Article
Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA).
Annals of the rheumatic diseases - 1 Jun 2013
Hughes-Austin Jan M, Deane Kevin D, Derber Lezlie A, Kolfenbach Jason R, Zerbe Gary O, Sokolove Jeremy, Lahey Lauren J, Weisman Michael H, Buckner Jane H, Mikuls Ted R, O'Dell James R, Keating Richard M, Gregersen Peter K, Robinson William H, Holers V Michael, Norris Jill M
Abstract excerpt
OBJECTIVE: We investigated whether rheumatoid arthritis (RA)-related autoantibodies were associated with systemic inflammation in a prospective cohort of first-degree relatives (FDRs) of RA probands, a population without RA but at increased risk for its future development. METHODS: We studied 44 autoantibody positive FDRs, of whom 29 were rheumatoid factor (RF) positive, 25 were positive for the high risk...
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