Article
HLA-DRB1 Analysis Identified a Genetically Unique Subset within Rheumatoid Arthritis and Distinct Genetic Background of Rheumatoid Factor Levels from Anticyclic Citrullinated Peptide Antibodies.
The Journal of rheumatology - 1 Apr 2018
Hiwa Ryosuke, Ikari Katsunori, Ohmura Koichiro, Nakabo Shuichiro, Matsuo Keitaro, Saji Hiroh, Yurugi Kimiko, Miura Yasuo, Maekawa Taira, Taniguchi Atsuo, Yamanaka Hisashi, Matsuda Fumihiko, Mimori Tsuneyo, Terao Chikashi
Abstract excerpt
OBJECTIVE: HLA-DRB1 is the most important locus associated with rheumatoid arthritis (RA) and anticitrullinated protein antibodies (ACPA). However, fluctuations of rheumatoid factor (RF) over the disease course have made it difficult to define fine subgroups according to consistent RF positivity for the analyses of genetic background and the levels of RF. METHODS: A total of 2873 patients with RA and 2008 healthy...
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