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Article

A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis.

Arthritis research & therapy - 1 Jan 2007

Gourraud Pierre-Antoine, Dieudé Philippe, Boyer Jean-Frédéric, Nogueira Leonor, Cambon-Thomsen Anne, Mazières Bernard, Cornélis François, Serre Guy, Cantagrel Alain, Constantin Arnaud

Abstract excerpt

The HLA-DRB1 gene was reported to be associated with anticitrullinated protein/peptide autoantibody (ACPA) production in rheumatoid arthritis (RA) patients. A new classification of HLA-DRB1 alleles, reshaping the shared epitope (SE) hypothesis, was recently found relevant in terms of RA susceptibility and structural severity. We investigated the relevance of this new classification of HLA-DRB1 SE+ alleles in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17328818
DOI: 10.1186/ar2131
PMCID: PMC1906795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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