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Genome-wide association studies reveal new insights into the genetic basis of IgG4-related disease in the Chinese Han population.

Annals of the rheumatic diseases - 1 Apr 2026

Yan Songxin, Peng Yu, Xu Jingkai, Liu Yanying, Li Zhan, Yang Yue, Peng Linyi, Zhou Jiaxin, Li Liubing, Liu Chenxi, Chen Haizhen, Wang Mu, Wu Ziyan, Zhang Shulan, Xu Honglin, Li Haolong, Feng Futai, Fei Yunyun, Chen Yu, Dong Lingli, Li Mengtao, Li Zhanguo, Zhang Fengchun, Zuo Xianbo, Zhang Wen, Li Yongzhe

Abstract excerpt

OBJECTIVES: IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder of unknown aetiology, potentially linked to genetic factors. This study conducted the first genome-wide association study on IgG4-RD in the Chinese Han population to identify genetic susceptibility loci. METHODS: The study analysed data from 1161 patients with IgG4-RD and 10,539 controls across 2 independent cohorts, with...

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PMID: 41298177
DOI: 10.1016/j.ard.2025.10.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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