Article
Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets.
Arthritis research & therapy - 1 Jan 2008
van der Helm-van Mil Annette H M, Huizinga Tom W J
Abstract excerpt
In the past few years considerable advances have been made in the genetics of susceptibility to rheumatoid arthritis (RA). For decades the HLA-DRB1 alleles were the only extensively replicated genetic factor, but more genetic risk factors have now been identified that predispose to RA. Interestingly, several of the observed genetic variants conferred risk to anticitrulline-peptide antibody (ACPA)-positive RA and...
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