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Article

Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation

14 Oct 2022

Abstract excerpt

Abstract Interleukin-9 (IL-9)-producing CD4+T helper cells (Th9) have been implicated in allergy/asthma and anti-tumor immunity, yet molecular insights on their differentiation from activated T cells, driven by IL-4 and transforming growth factor-beta (TGF-β), is still lacking. Here we show opposing functions of two transcription factors, D-binding protein (DBP) and E2F8, in controlling Th9 differentiation....

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PMID: 36241625
DOI: 10.1038/s41467-022-33733-8

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