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Article

E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases

19 Mar 2020

Abstract excerpt

T follicular helper (Tfh) cells are indispensable for the formation of germinal center (GC) reactions, whereas T follicular regulatory (Tfr) cells inhibit Tfh-mediated GC responses. Aberrant activation of Tfh cells contributes substantially to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). Nonetheless, the molecular mechanisms mitigating excessive Tfh cell differentiation are...

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PMID: 32191636
DOI: 10.1172/jci129018

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