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Article

BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy

5 Mar 2021

Abstract excerpt

TGFβ is essential for the generation of anti-tumor Th9 cells; on the other hand, it causes resistance against anti-tumor immunity. Despite recent progress, the underlying mechanism reconciling the double-edged effect of TGFβ signaling in Th9-mediated cancer immunotherapy remains elusive. Here, we find that TGFβ-induced down-regulation of bifunctional apoptosis regulator (BFAR) represents the key mechanism...

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PMID: 33914044
DOI: 10.1084/jem.20202144

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