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Article

The multifaceted role of SMAD4 in immune cell function

17 Dec 2024

Abstract excerpt

The Transforming Growth Factor-beta (TGF-β) signaling pathway, with SMAD4 as its central mediator, plays a pivotal role in regulating cellular functions, including growth, differentiation, apoptosis, and immune responses. While extensive research has elucidated SMAD4's role in tumorigenesis, its functions within immune cells remain underexplored. This review synthesizes current knowledge on SMAD4's diverse roles...

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PMID: 39802394
DOI: 10.1016/j.bbrep.2024.101902

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