Cutting Edge: Smad2 and Smad4 Regulate TGF-β–Mediated Il9 Gene Expression via EZH2 Displacement

Abstract excerpt

IL-9 is a proallergic cytokine produced by a newly proposed Th cell subset, Th9. Th9 cells can be generated by treatment of naive T cells with TGF-β and IL-4 in vitro. However, it is still not clear how TGF-β signaling regulates Th9 differentiation. In this study, we demonstrate that Smad2 and Smad4, two transcriptional factors activated by TGF-β signaling, are required for Th9 differentiation in vitro....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Lymphoma Diagnosis and Treatment
• Share to T-cell and B-cell Immunology
• Share to TGF-β signaling in diseases