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Article

The regulation of DOCK family proteins on T and B cells

15 Jun 2020

Abstract excerpt

The dedicator of cytokinesis (DOCK) family proteins consist of 11 members, each of which contains 2 domains, DOCK homology region (DHR)-1 and DHR-2, and as guanine nucleotide exchange factors, they mediate activation of small GTPases. Both DOCK2 and DOCK8 deficiencies in humans can cause severe combined immunodeficiency, but they have different characteristics. DOCK8 defect mainly causes high IgE, allergic...

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PMID: 32542827
DOI: 10.1002/jlb.1mr0520-221rr

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