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Article

KRAS, NRAS, BRAF, PIK3CA, and AKT1 signatures in colorectal cancer patients in south-eastern Romania.

Medicine - 7 Oct 2022

Brinzan Costel Stelian, Aschie Mariana, Cozaru Georgeta Camelia, Deacu Mariana, Dumitru Eugen, Burlacu Ionut, Mitroi Anca

Abstract excerpt

Somatic mutations in the oncogenes of the epidermal growth factor receptor signaling pathway play vital roles in colorectal carcinogenesis and have been closely linked with clinical resistance to monoclonal therapy. In this study, we have analyzed the mutation frequencies of 5 genes and compared the genetic findings with clinicopathological variables in order to determine diagnostically relevant alterations and...

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Identifiers

PMID: 36221415
DOI: 10.1097/MD.0000000000030979
PMCID: PMC9542653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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KRAS, NRAS, BRAF, PIK3CA, and AKT1 signatures in colorectal cancer patients in south-eastern Romania.PMID 36221415Read ↗

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