Prognostic impact of KRAS, NRAS, BRAF, and PIK3CA mutations in primary colorectal carcinomas: a population-based study.

doi:10.1186/s12967-016-1053-z

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Article

Prognostic impact of KRAS, NRAS, BRAF, and PIK3CA mutations in primary colorectal carcinomas: a population-based study.

Journal of translational medicine - 13 Oct 2016

Palomba Grazia, Doneddu Valentina, Cossu Antonio, Paliogiannis Panagiotis, Manca Antonella, Casula Milena, Colombino Maria, Lanzillo Annamaria, Defraia Efisio, Pazzola Antonio, Sanna Giovanni, Putzu Carlo, Ortu Salvatore, Scartozzi Mario, Ionta Maria Teresa, Baldino Giovanni, Sarobba Giuseppina, Capelli Francesca, Sedda Tito, Virdis Luciano, Barca Michela, Gramignano Giulia, Budroni Mario, Tanda Francesco, Palmieri Giuseppe

Abstract excerpt

BACKGROUND: Activation of oncogenes downstream the EGFR gene contributes to colorectal tumorigenesis and determines the sensitivity to anti-EGFR treatments. The aim of this study was to evaluate the prognostic value of KRAS, BRAF, NRAS and PIK3CA mutations in a large collection of CRC patients from genetically-homogeneous Sardinian population. METHODS: A total of 1284 Sardinian patients with histologically-proven...

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PMID: 27737711
DOI: 10.1186/s12967-016-1053-z
PMCID: PMC5064898

Genes

BRAF
KRAS
NRAS
EGFR

Provenance

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