Article
Association between clinicopathological characteristics and RAS mutation in colorectal cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2018
Rimbert Johan, Tachon Gaëlle, Junca Audelaure, Villalva Claire, Karayan-Tapon Lucie, Tougeron David
Abstract excerpt
In colorectal cancer, KRAS (exons 2, 3, and 4) and NRAS (exons 2, 3, and 4) mutations are associated with resistance to antiepidermal growth factor receptor monoclonal antibodies, and BRAF mutation is a molecular marker of poor prognosis. KRAS exon 2 and BRAF-mutated colorectal cancers have well-...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Colorectal Neoplasms
- Female
- GTP Phosphohydrolases
- Humans
- Male
- Membrane Proteins
- Middle Aged
- Mutation
- Prognosis
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins p21(ras)
- Retrospective Studies