Clinical, Pathological and Molecular Insights on KRAS, NRAS, BRAF, PIK3CA and TP53 Mutations in Metastatic Colorectal Cancer Patients from Northeastern Romania.

doi:10.3390/ijms241612679

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Clinical, Pathological and Molecular Insights on KRAS, NRAS, BRAF, PIK3CA and TP53 Mutations in Metastatic Colorectal Cancer Patients from Northeastern Romania.

International journal of molecular sciences - 11 Aug 2023

Afrăsânie Vlad-Adrian, Marinca Mihai-Vasile, Gafton Bogdan, Alexa-Stratulat Teodora, Rusu Alexandra, Froicu Eliza-Maria, Sur Daniel, Lungulescu Cristian Virgil, Popovici Larisa, Lefter Andrei-Vlad, Afrăsânie Irina, Ivanov Anca-Viorica, Miron Lucian, Rusu Cristina

Abstract excerpt

Mutations in RAS, BRAF, PIK3CA, and TP53 are well-established genetic abnormalities in metastatic colorectal cancer (mCRC). However, limited information is available for patients from Eastern Europe, including Romania. In this retrospective analysis, we investigated 104 mCRC patients from the Northeastern region of Romania to determine the frequency, distribution, coexistence, and clinicopathological and...

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PMID: 37628868
DOI: 10.3390/ijms241612679
PMCID: PMC10454287

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