KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics.

doi:10.1016/j.critrevonc.2023.103987

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Article

KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics.

Critical reviews in oncology/hematology - 1 Jun 2023

Voutsadakis Ioannis A

Abstract excerpt

BACKGROUND: Colorectal cancer is one of the most prevalent malignancies and its molecular pathogenesis has been intensely investigated for several decades. As a result, great progress has been made and targeted therapies have been introduced in the clinic. This paper examines colorectal cancers b...

Topics

Humans
Class I Phosphatidylinositol 3-Kinases
Colorectal Neoplasms
Microsatellite Instability
Mutation
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)

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